Although there are people who enjoy pain, for example the masochistic, but most people do not like pain. Headache, joint pain, back pain to cancer pain that is chronic rarely got a good response from anyone. The pain can greatly affect a person's ability to move and greatly affect quality of life.
International Association for the Study of Pain (IASP) defines pain as a sensory and emotional experience that is not fun to damage the actual or potential tissue. Due to the discomfort caused by pain, often pain is the main reason even less is the only reason that brings a patient to consult a doctor.
Until now many doctors from around the world and from many fields are often confused with the reduction of pain in patients, especially in chronic pain. Sometimes dilemma arises when should give anti-pain medication can cause addiction like morphine group. Seeing how important this painful problem for everyone, WHO (World Health Organization) and various scientists around the world busy constantly looking for ways the best pain relief that can be given to patients.
Dr Kenneth Hargreaves, DDS, Ph.D., head of the research team from The University of Texas Health Science Center at San Antonio is one of those who began the study of the mechanisms of pain and how to cope more effectively.
They start by studying the chili. They found that there is capsaicin in chili peppers that causes us to feel a burning sensation as when eating spicy chili. Furthermore, they found that in a variety of conditions that cause pain, the body produces a substance similar to capsaicin in chili. These substances form a fatty acid called Linoleic Acid Oxidized metabolites (OLAMs) that activate TRPV1 receptor protein in nerve cells of pain.
The researchers are continuing their research in order to find anti-pain medication that can work directly on TRPV1 pain receptors or associated with OLAMs. Currently, further research on this has resulted in two anti-pain medication classes that can inhibit the formation of OLAMs and the form of antibodies to inactivate the OLAMs work. They believe that a new generation of anti-pain can help overcome chronic pain such as cancer, migraines, pain in diabetes and AIDS.
Research continues to be able to minimize the adverse effects of hyperthermia (elevated body temperature) on the new generation of drugs that can be used is optimally
International Association for the Study of Pain (IASP) defines pain as a sensory and emotional experience that is not fun to damage the actual or potential tissue. Due to the discomfort caused by pain, often pain is the main reason even less is the only reason that brings a patient to consult a doctor.
Until now many doctors from around the world and from many fields are often confused with the reduction of pain in patients, especially in chronic pain. Sometimes dilemma arises when should give anti-pain medication can cause addiction like morphine group. Seeing how important this painful problem for everyone, WHO (World Health Organization) and various scientists around the world busy constantly looking for ways the best pain relief that can be given to patients.
Dr Kenneth Hargreaves, DDS, Ph.D., head of the research team from The University of Texas Health Science Center at San Antonio is one of those who began the study of the mechanisms of pain and how to cope more effectively.
They start by studying the chili. They found that there is capsaicin in chili peppers that causes us to feel a burning sensation as when eating spicy chili. Furthermore, they found that in a variety of conditions that cause pain, the body produces a substance similar to capsaicin in chili. These substances form a fatty acid called Linoleic Acid Oxidized metabolites (OLAMs) that activate TRPV1 receptor protein in nerve cells of pain.
The researchers are continuing their research in order to find anti-pain medication that can work directly on TRPV1 pain receptors or associated with OLAMs. Currently, further research on this has resulted in two anti-pain medication classes that can inhibit the formation of OLAMs and the form of antibodies to inactivate the OLAMs work. They believe that a new generation of anti-pain can help overcome chronic pain such as cancer, migraines, pain in diabetes and AIDS.
Research continues to be able to minimize the adverse effects of hyperthermia (elevated body temperature) on the new generation of drugs that can be used is optimally
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